Aspirnaut™ Co-Authorships

Aspirnauts help expand the leading edge of new knowledge by conducting discovery science research. High school, undergraduate, and graduate students have been recognized as co-authors of scientific publications. One publication featured over 80 Aspirnaut co-authors in the leading journal Proceedings of the National Academy of Sciences (PNAS).

2025

Depletion of Polypyrimidine tract binding protein 1 (PTBP1) activates Müller glia-derived proliferation during zebrafish retina regeneration via modulation of the senescence secretome

Experimental Eye Research | Issue 257, 2025

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α-Parvin regulation of cell re-arrangement is critical for ureteric bud branching morphogenesis

bioRxiv | Dec 8 2025

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Pharmacological inhibition of MCL-1 disrupts mitochondrial cristae and depletes the human neural progenitor cell pool

bioRxiv | December 22, 2025

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The staphylococcal collagen adhesion CNA35 effectively detects collagen and its fragments in blots after SDS-PAGE

ScienceDirect | May 2025

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Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism

The Journal of Immunology | April 9, 2025

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Analysis of the senescence secretome during zebrafish retina regeneration

Frontiers in Aging | Issue 6, 2025

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Sex differences in the Biosynthesis and Metabolism of Dihydrotestosterone in the Rat Kidney

Psychology | Volume 40, Issue S1

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Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment

Journal of Immunology | Oct 11 2025

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Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution, and adaptation

JBC | April 11, 2025

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2023

Collagen IV of basement membranes: III. Chloride pressure is a primordial innovation that drives and maintains the assembly of scaffolds

JBC | November 2023

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Collagen IV of basement membranes: II. Emergence of Collagen IVα345 enabled the assembly of compact GBM as an ultrafilter in mammalian kidneys

JBC | October 28, 2023

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Collagen IV of basement membranes: IV. Adaptive mechanism of collagen IV scaffold assembly in Drosophila

JBC | October 16, 2023

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Defining mitochondrial cristae morphology changes induced by aging in brown adipose tissue

JBC | November 2023

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The role of learned song in the evolution and speciation of Eastern and Spotted towhees

bioRxiv| May 16, 2023

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2021

Collagen IVα345 dysfunction in glomerular basement membrane diseases. III. A functional framework for α345 hexamer assembly

Journal of Biological Chemistry | January – June 2021

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Collagen IVα345 dysfunction in glomerular basement membrane diseases. I. Discovery of a COL4A3 variant in familial Goodpasture’s and Alport diseases

Journal of Biological Chemistry | January – June 2021

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ELAVL1 primarily couples mRNA stability with the 3′ UTRs of interferon-stimulated genes

Cell Reports | May 25, 2021

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2020

Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies

Nature Medicine | January 13, 2020 | pages 26, 98-109

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Cotranslational folding stimulates programmed ribosomal frameshifting in the alphavirus structural polyprotein

Journal of Biological Chemistry | January 17, 2020

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Chronic femoral diaphyseal osteomyelitis with radiographs initially concerning for Paget disease of the bone

Radiology Case Reports | April 2020 | pages 344-348

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Clostridioides difficile proline fermentation in response to commensal clostridia

ScienceDirect | June 2020 | Volume 63

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EGF Receptor–Mediated FUS Phosphorylation Promotes Its Nuclear Translocation and Fibrotic Signaling

Journal of Cell Biology | September 7, 2020

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2019

Aspirnaut: a Rural High School Pipeline to Increase Diversity in STEM

Nature Reviews Nephrology | August 8, 2019 | pages 591-592

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CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-medidated volume regulated anion channels independently of the receptor

Am J Physiol Cell Physiol | October 7, 2019 | pages 857-866

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Discovery and characterization of 2-nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)-N-(pyridine-4-ylmethyl) anilines as novel inhibitors of the Aedes aegypti Kir 1 (AeKir1) channel

ACS Infectious Diseases | March 4, 2019 | pages 5, 6, 917-931

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Changes in urinary metabolome related to body fat involved intermediates of choline processing by gut microbiota

Heliyon | April 11, 2019

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Cotranslational folding stimulates programmed ribosomal frameshifting in the alphavirus structural polyprotein

bioRxiv | 2019

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A chloride ring is an ancient evolutionary innovation mediating the assembly of the collagen IV scaffold of basement membranes

J Biol Chem | March 28, 2019 | pages 294:7968-7981

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Respiratory heterogeneity shapes biofilm formation and host colonization in uropathogenic Escherichia coli

mBio | April 2, 2019

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2018

Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: differential effects on topoisomerase Iiα and Iiβ

Bioorganic & Medicinal Chemistry Letters | September 15, 2018 | pages 2961-2968

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Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

Nucleic Acids Research | April 20, 2018 | pages 3458-3467

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Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains

Scientific Reports | February 3, 2018 | pages 258-271

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Unicellular ancestry and mechanisms of diversification of Goodpasture-antigen binding protein

The Journal of Biological Chemistry | November 1, 2018

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Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992

Molecular Pharmacology | August 2018 | pages 926-937

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Effect of Temperature on the release of Proterometra macrostoma (Trematoda: Digenea) cercariae from their snail intermediate host, Pleurocera semicarinata (Gastropoda: Pleuroceridae) at North Elkhorn Creek, Kentucky

Comparative Parasitology | July 1, 2018 | pages 202-207

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2017

Blocking TGF-β and β-catenin epithelial crosstalkexacerbates CKD

Journal of the American Society of Nephrology | December 28, 2017 | pages 3490-3503

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Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Nature Communications | September 29, 2017 | Article 750

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Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis

Matrix Biology | January 2017 | pages 258-271

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Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming

Matrix Biology | January 2017 | pages 931-939

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2016

Basement membrane ultrastructure and component localization data from uterine tissues during early mouse pregnancy

Data in Brief | November 5, 2016 | pages 931-939

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A pH-mediated topological switch within the n-terminal domain of humnan caveolin-3

Biophysical Journal | June 7, 2016 | pages 2475-2485

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Extracellular chloride signals collagen IV network assembly during basement membrane formation

JCB | May 23, 2016 | pages 479-494

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2015

Pyridoxamine protects proteins from damage by hypohalous acids in vitro and in vivo

Free Radical Biology & Medicine | December 2015 | pages 83-90

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The Ancient Immunoglobulin Domains of Peroxidasin Are Required to Form Sulfilimine Cross-links in Collagen IV

Journal of Biological Chemistry | August 28, 2015 | pages 21741-21748

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5′-O-Alkylpyridoxamines: Lipophilic Analogues of Pyridoxamine Are Potent Scavengers of 1,2-Dicarbonyls

Chemical Research in Toxicology | July 20, 2015 | pages 1469-1475

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Hypohalous acids contribute to renal extracellular matrix damage in experimental diabetes

Diabetes | June 2015 | pages 2242-2253

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Alterations of urinary metabolite profile in model diabetic nephropathy

Biochemical and biophysical research communications | January 9, 2015 | pages 610-614

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2014

Supramolecular organization of the α121-α565 collagen IV network

JBC | September 12, 2014 | pages 25601-25610

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TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase eta

Development | January 2014 | pages 1332-1341

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A unique covalent bond in basement membrane is a primordial innovation for tissue evolution

PNAS | January 7, 2014 | pages 331-336

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2012

Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis

Nature Chemical Biology | September 2012 | pages 784-790

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Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues

Biochemical and Biophysical Research Communications | August 5, 2011 | pages 574-579

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Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues

Biochemistry Vol 50, Issue 27 | July 12, 2011 | pages 6102-6112

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